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KMID : 0363320000210010087
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Journal of Korean Oriental Internal Medicine
2000 Volume.21 No. 1 p.87 ~ p.99
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A Comparative study on the inhibitory effect on contraction of isolated organs, anti-ulcer, secretion of gastric juice, secretion of gastrin in serum, transport ability of intestine, analgesic effect and sedative effect of the Bosimgunbitang(ÜÍãýËíÞ¡÷·) and ungjungamiijintang(ïáîîÊ¥Ú«ì£òç÷·)
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Kim Jin-Sung
Ryu Bong-Ha
Park Dong-Won
Ryu Ki-Won
Yoon Sang-Gun
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Abstract
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Objectives : This is the experimetal paper to evaluate and compare the effects of Bosimgunbitang(ÜÍãýËíÞ¡÷·) with those of Jungjungamiyijintang(ïáîîÊ¥Ú«ì£òç÷·) on contraction of isolated organs, anti-ulcer, secretion of gastric juice, secretion of gastrin in serum, transport ability of intestine, analgesic effect and sedative effect
Methods : We used mice and rats administered with the extract of the above herbs.
Results: Bosimgunbitang and jungjungamiijintang showed the inhibitory effect on the smooth muscle contraction of the isolated ileum induced by acethylcholine chloride and barium chloride in mice. transport ability of intestine. Bosimgunbitang and jungjungamiijintang showed the inhibitory effect on the contraction of the fundus-strip induced by acethylcholine chloride and barium chloride in rats. The preventive effect on pyloric ulcer, indomethacin induced ulcer and ethanol-HCl induced ulcer bf mice was significant. The inhibitory effect of Bosimgunbitang on gastric free acidity, total acidity in Shay rats was significant. The inhibitory effect of on gastrin secretion in serum was significant after only 1 hour when the Bosimgunbitang and jungjungamiijintang was administered. The promoting effect of the jungjungamiijintang on the transport ability of small intestine was significant in the high concentration. The promoting effect of the Bosimgunbitang and jungjungamiijintang on the transport ability of large intestine was significant. The analgesic and the sedative effect were recognized. It meaned that Bosimgunbitang and jungjungamiijintang effected on the C.N.S..
Conclusion : Bosimgunbitang and jungjungamiijintang have the inhibitory effect on the smooth muscle abnormal contraction of the isolated ileum and the anti-ulcer effect to prevent, secretion of gastric juice and gastrin in serum. And they also have to increase a transport ability of intestine, analgesic effect and sedative effect. Jungjungamiijintang especially is eminent for analgesic effect while Bosimgunbitang has excellent sedative effect.
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KEYWORD
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Bosimgunbitang, jungjungamiijintang, contraction of isolated organs, anti-ulcer, gastric juice, gastrin, intestinal transport ability, analgesic effect, sedative effect
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